Gangrene is the death of an organ or body tissue. When the blood supply is cut off, the tissue does not get enough oxygen and begins to die. If the gangrene is widespread, shock can occur.

There are three main types:

• Dry gangrene—lack of blood supply causes the tissue to dry up and slough off
• Wet gangrene—usually occurs when the tissue is infected with bacteria, tissue becomes moist and breaks down
• Gas gangrene—a particular type of bacteria (Clostridia) produces gas bubbles in the tissue

• Infection, especially after surgery or injury
• Diabetes
• Any condition that blocks blood flow to tissue (such as, atherosclerosis)

• Smoking
• Alcohol use
• Traumatic injury, especially crushing injuries
• Wound infection after surgery
• Frostbite
• Burns
• Atherosclerosis
• Diabetes
• Raynauds disease
• Blood clots
• Ruptured appendix
• Hernia
• IV drug use

• Blood tests
• Tests of the discharge and the tissue
• X-ray—a test that uses radiation to take pictures of structures inside the body
• CT scan—a type of x-ray that uses a computer to make pictures of the inside of the body
• MRI scan—a test that uses magnetic waves to make pictures of the inside of the body

• Antibiotics—given through IV in a very potent form
• Blood thinners—given to prevent blood clots
• Debridement—surgical procedure to cut away dead and dying tissue, done to try to avoid gangrene from spreading
• Amputation— removal of severely affected body part (such as, toe or foot amputation, above-the-knee amputation)
• Hyperbaric oxygen treatment—involves exposing the affected tissue to oxygen at high pressure