Depression can be devastating to family relationships, friendships, and the ability to work or go to school. Symptoms of depression vary a great deal from person to person. Some people have only a few symptoms, while others have many.

Symptoms can change over time and may include:

  • Persistent feelings of sadness, emptiness, or hopelessness
  • Feeling guilty, worthless, or helpless
  • Loss of interest in hobbies and activities
  • Loss of interest in sex
  • Feeling tired
  • Trouble concentrating, remembering, or making decisions
  • Trouble sleeping, waking up too early, or oversleeping
  • Eating more or less than usual
  • Weight gain or weight loss
  • Restlessness, irritability, or anxiety
  • Physical symptoms that defy standard diagnosis and do not respond well to medical treatments
  • Thoughts of death or suicide (with or without suicide attempts)

Depression often coexists with other conditions. The stress of coping with the disease may cause depression. Or depression may be caused by the disease itself or by drugs used to treat the disease. Disorders commonly associated with depression include: