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Surgery may be indicated for persistent back pain that involves an anatomical problem such as a herniated disc, spinal stenosis, or spondylolisthesis. Rarely, surgery may be performed on an emergency basis if there are severe symptoms, such as loss of bowel or bladder control, or if a tumor is present.

The two main surgical options to treat a herniated disc are laminectomy (with or without spinal fusion) and diskectomy. Spinal decompression may be done to treat spinal stenosis. Spondylolisthesis is treated either with a fusion or with a fusion and a decompression.