The herbs chaparral ( Larrea tridentata or L. mexicana), comfrey (Symphytum officinale), and coltsfoot (Tussilago farfara) contain liver-toxic substances. Because amiodarone can also be hard on the liver, combining these herbs with the medication is not advisable.

Amiodarone has been reported to cause increased sensitivity to the sun, amplifying the risk of sunburn or skin rash. Because St. John's wort and dong quai may also cause this problem, taking these herbal supplements during amiodarone therapy might add to this risk.

It may be a good idea to wear a sunscreen or protective clothing during sun exposure if you take one of these herbs while using amiodarone.