TUESDAY, Aug. 23 (HealthDay News) -- A common form of heart
trouble called diastolic dysfunction appears to worsen over time
and may lead to an increased risk of heart failure, new research
In people with diastolic dysfunction, which often comes with
advancing age, the heart's left ventricle fills with blood in an
abnormal way and is accompanied by elevated filling pressures.
The new study included more than 2,000 people aged 45 and older
who participated in Minnesota's Olmsted County Heart Function
Study. They were assessed from 1997 to 2000, and their diastolic
left ventricular function was graded as being normal or having
mild, moderate or severe dysfunction.
Participants were invited back for a second examination between
2001 and 2004, and more than 1,400 of them underwent follow-up
testing for new-onset heart failure between 2004 and 2010.
Between the first and second examination, the prevalence of
diastolic dysfunction of any degree increased from about 24 percent
to more than 39 percent. Moderate or severe diastolic dysfunction
rose from 6.4 percent to 16 percent.
During the four years between examinations, diastolic function
worsened in just over 23 percent of participants, remained
unchanged in about 68 percent and improved in around 9 percent.
Older people, especially those over 65, were more likely to
develop diastolic dysfunction.
During the more than six years of follow-up after the second
examination, 81 people developed heart failure. Those aged 65 and
older were most likely to develop heart failure. Persistent or
worsening diastolic dysfunction was associated with heart failure,
the researchers said.
The study is published Aug. 24 in the
Journal of the American Medical Association.
"Cumulative heart failure incidence was 2.6 percent in participants whose diastolic function remained normal or normalized between examinations; 7.8 percent in those with persistent, or progression to mild diastolic dysfunction; and 12.2 percent in those with persistent, or progression to moderate or severe diastolic dysfunction," wrote Dr. Garvan C. Kane, of the Mayo Clinic and Medical School in Rochester, Minn., and colleagues in a journal news release.
The U.S. National Heart, Lung, and Blood Institute has more