Biologic Agents and the Treatment of Autoimmune Disorders | Side Effects of Biologic Agents | A Step Forward in Medicine

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The immune system plays a vital role in keeping the body healthy. It is made up of a complex network of cells and organs that work together to defend the body against foreign invaders.

While traditional pharmaceuticals are made up of chemicals, biologic agents are actually developed using proteins from living cells. They are designed to act on different parts of the inflammatory system in order to evoke specific, targeted effects.

Biologic Agents and the Treatment of Autoimmune Disorders

In autoimmune disorders, the immune system is overactive and destroys not only foreign substances, but also the body’s own tissues. The goal of biologic therapy is to slow or block specific components of the immune system and halt tissue destruction.

Autoimmune disorders treated with biologic agents include:

  • Psoriasis: This is a chronic skin disorder that not only causes skin lesions, but also problems with the joints, fingernails and toenails, genitals, and inside of the mouth. In psoriasis, certain immune cells become overactive, which results in psoriatic lesions developing on the skin and arthritis symptoms developing in the joints.
  • Rheumatoid arthritis (RA): RA is a chronic inflammation of the lining of the joints that results in pain, stiffness, swelling, damage, and loss of function. In RA, the immune system initiates chronic inflammation of the lining of the joints.
  • Multiple sclerosis (MS): MS is a chronic debilitating disease in which the immune system attacks the coating (called myelin) of the nerve fibers in the brain and spinal cord. This causes inflammation and injury to the sheath and the nerves. It can cause problems with coordination, balance, speaking, and walking.

Side Effects of Biologic Agents

Side effects depend on many factors such as the type of biologic, dosage, route of administration, schedule, and how your body reacts to the biologic agents. Some possible side effects of biologic therapies are:

If your doctor recommends biologic therapy, ask him about which specific side effects you may experience.

A Step Forward in Medicine

Many biologic agents have been approved by the FDA (see the following table), and many more are under development.

Examples of Approved Biologic Agents for Autoimmune Disorders

Brand name

Biologic Agent

Disease State

Amevive

alefacept

psoriasis

Stelara

ustekinumab

psoriasis

Enbrel

etanercept

psoriatic arthritis; rheumatoid arthritis; juvenile rheumatoid arthritis and more

Humira

adalimumab

rheumatoid arthritis, crohn's disease, psoriasis and more

Remicade

infliximab

rheumatoid arthritis; Crohn’s disease

Kineret

anakinra

rheumatoid arthritis

Avonex, Rebif

interferon beta

multiple sclerosis